Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP10 | P09238 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11249246 | 0.99 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3HTR1ASIGMAR1 | |
| SCHEMBL11239682 | 0.92 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3HTR1ASIGMAR1 | |
| Bromide SCHEMBL11242341 | 0.91 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3HTR1ASIGMAR1 | |
| SCHEMBL11248093 | 0.80 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3HTR1ASIGMAR1 | |
| SCHEMBL11243000 | 0.79 | USP2 (0.43) | KCNH2CYP2D6TSPOGAA | |
| Bromide SCHEMBL11470442 | 0.79 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR1ASIGMAR1 | |
| SCHEMBL27626859 | 0.79 | SIGMAR1 (0.39) | SLC6A2SLC6A4SLC6A3SIGMAR1MMP3 | |
| SCHEMBL7482884 | 0.78 | SIGMAR1 (0.67) | SLC6A2SLC6A4SLC6A3HTR1ASIGMAR1 | |
| SCHEMBL11477208 | 0.78 | SIGMAR1 (0.44) | SLC6A2SLC6A4SLC6A3HTR1ASIGMAR1 | |
| SCHEMBL373568 | 0.76 | OPRM1 (0.50) | CYP2D6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016261-B1 | SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | disclosed |
| EP-0016261-A1 | Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-01 | — | — | EP | disclosed |