Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254574 | 0.82 | ALDH1A1 (0.46) | KMT2ATSHRLMNAOPRM1 | |
| SCHEMBL11244360 | 0.81 | LMNA (0.41) | HSD11B1AKR1C1KMT2ALMNAHTT | |
| SCHEMBL11492175 | 0.78 | SLC22A1 (0.50) | KMT2ATSHROPRM1 | |
| SCHEMBL11492176 | 0.78 | SLC22A1 (0.50) | KMT2ATSHROPRM1 | |
| SCHEMBL11651250 | 0.78 | SLC22A1 (0.50) | KMT2ATSHROPRM1 | |
| SCHEMBL11651256 | 0.78 | SLC22A1 (0.50) | KMT2ATSHROPRM1 | |
| SCHEMBL11487518 | 0.78 | SLC22A1 (0.50) | KMT2ATSHROPRM1 | |
| SCHEMBL11250668 | 0.71 | GAA (0.44) | KMT2ATSHRHTTCYP1A2OPRM1 | |
| SCHEMBL11252284 | 0.70 | LMNA (0.39) | HSD11B1AKR1C1KMT2ALMNAHTT | |
| SCHEMBL4608031 | 0.69 | AKR1C1 (0.38) | AKR1C1LMNAHTTHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337341-A | 4a-Aryl-octahydro-1H-2-pyrindines | ELI LILLY AND COMPANY (US) | 1982-06-29 | — | — | US | disclosed |