Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TET3 | O43151 | 1/20 | 0.34 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.34 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11252284 | 0.89 | LMNA (0.39) | LMNAKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL11256394 | 0.85 | LMNA (0.42) | LMNAKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL11244801 | 0.85 | LMNA (0.42) | LMNAKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL11248709 | 0.81 | HSD11B1 (0.45) | LMNAKMT2AAKR1C1HTTHSD11B1 | |
| SCHEMBL11247876 | 0.72 | HTR2A (0.43) | SLC6A2SLC6A4 | |
| Benzoic Acid SCHEMBL10818979 | 0.71 | MEN1 (0.36) | LMNAKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL11079566 | 0.70 | MEN1 (0.33) | KMT2AMEN1ALDH1A1POLBHTT | |
| SCHEMBL10631400 | 0.68 | LMNA (0.40) | LMNAKMT2AMEN1ALDH1A1AKR1C1 | |
| SCHEMBL1665886 | 0.66 | TSHR (0.42) | — | |
| SCHEMBL4608031 | 0.66 | AKR1C1 (0.38) | LMNAAKR1C1RAB9AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337341-A | 4a-Aryl-octahydro-1H-2-pyrindines | ELI LILLY AND COMPANY (US) | 1982-06-29 | — | — | US | disclosed |