Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263093 | 0.87 | TDO2 (0.41) | TDO2PDE3BPDE3AKMT2AMEN1 | |
| SCHEMBL11253084 | 0.86 | ALDH1A1 (0.36) | TDO2KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL11261674 | 0.86 | TDO2 (0.36) | TDO2IDO1KMT2AMEN1CYP1A2 | |
| SCHEMBL11251011 | 0.86 | BCHE (0.44) | TDO2PDE3BPDE3AALDH1A1ERBB2 | |
| SCHEMBL11261938 | 0.83 | ALDH1A1 (0.43) | PDE3BPDE3AKMT2AMEN1ALDH1A1 | |
| SCHEMBL11252484 | 0.83 | HSP90AA1 (0.35) | TDO2ALDH1A1 | |
| SCHEMBL11254978 | 0.83 | SYK (0.35) | TDO2KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL11254049 | 0.83 | TDO2 (0.37) | TDO2NPSR1KDM4E | |
| SCHEMBL11262405 | 0.82 | TDO2 (0.48) | TDO2IDO1PDE3BPDE3AKMT2A | |
| SCHEMBL11256404 | 0.81 | TDO2 (0.47) | TDO2IDO1PDE3BPDE3AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |