Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.46 |
| ▸ | HTR3A | P46098 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11427938 | 0.99 | HTR1A (0.45) | HTR1AHTR3AALDH1A1GLAL3MBTL1 | |
| SCHEMBL11253111 | 0.91 | HTR1A (0.43) | HTR1AHTR3AALDH1A1L3MBTL1SLC6A9 | |
| Bromide SCHEMBL11427829 | 0.89 | HTR1A (0.42) | HTR1AHTR3AALDH1A1L3MBTL1SLC6A9 | |
| SCHEMBL11248404 | 0.82 | SMN1; SMN2 (0.43) | HTR1AHTR3AALDH1A1GLAL3MBTL1 | |
| SCHEMBL11249100 | 0.81 | HTR1A (0.43) | HTR1AHTR3AALDH1A1GLAL3MBTL1 | |
| SCHEMBL4702082 | 0.81 | HTR1A (0.50) | HTR1AHTR3AALDH1A1GLAL3MBTL1 | |
| Bromide SCHEMBL11248578 | 0.81 | HTR1A (0.43) | HTR1AHTR3AALDH1A1GLAL3MBTL1 | |
| SCHEMBL11248843 | 0.81 | ALDH1A1 (0.42) | HTR1AHTR3AALDH1A1GLAL3MBTL1 | |
| SCHEMBL11477972 | 0.80 | HTR1A (0.41) | HTR1AHTR3AALDH1A1L3MBTL1SLC6A9 | |
| Hydrochloric Acid SCHEMBL11476881 | 0.79 | HTR1A (0.43) | HTR1AHTR3AALDH1A1L3MBTL1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4198419-A | Phenylthiophenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | claimed |
| EP-0013424-B1 | SPIRO(DIBENZO(B,F)THIEPINE-PIPERIDINES), INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | disclosed |
| EP-0013424-A1 | Spiro(dibenzo(b,f)thiepine-piperidines), intermediate products for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | disclosed |
| US-4198420-A | Spiro[dibenz(b,f)thiepin-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |
| US-4198419-A | Phenylthiophenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |