Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248843 | 0.88 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1SLC6A9L3MBTL1GLA | |
| SCHEMBL11258115 | 0.88 | RHEB (0.44) | SMN1; SMN2KDM4ENPY1RNPY2RALDH1A1 | |
| SCHEMBL11249097 | 0.82 | HTR1A (0.46) | SMN1; SMN2ALDH1A1OPRM1SLC6A9L3MBTL1 | |
| SCHEMBL11248413 | 0.82 | SLC6A9 (0.43) | SMN1; SMN2KDM4ENPY1RNPY2RALDH1A1 | |
| SCHEMBL11483187 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4ENPY1RNPY2RALDH1A1 | |
| Bromide SCHEMBL11427938 | 0.81 | HTR1A (0.45) | SMN1; SMN2ALDH1A1OPRM1SLC6A9L3MBTL1 | |
| Oxalic Acid SCHEMBL11487121 | 0.80 | KDM4E (0.50) | SMN1; SMN2KDM4ENPY1RNPY2RALDH1A1 | |
| SCHEMBL11477255 | 0.80 | KDM4E (0.53) | SMN1; SMN2KDM4EALDH1A1MAPTOPRM1 | |
| SCHEMBL11482078 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4ENPY1RNPY2RALDH1A1 | |
| SCHEMBL11477977 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4ENPY1RNPY2RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4198419-A | Phenylthiophenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | claimed |
| EP-0013424-B1 | SPIRO(DIBENZO(B,F)THIEPINE-PIPERIDINES), INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | disclosed |
| EP-0013424-A1 | Spiro(dibenzo(b,f)thiepine-piperidines), intermediate products for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | disclosed |
| US-4198420-A | Spiro[dibenz(b,f)thiepin-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |
| US-4198419-A | Phenylthiophenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |