Sugi Predict

Sugi Predict / Compounds / SCHEMBL11249172

SCHEMBL11249172

SCHEMBL11249172

CNCCN1CCN(S(C)(=O)=O)CC1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CARM1 Q86X55 4/20 0.54
▸ PRMT6 Q96LA8 4/20 0.54
▸ PRMT8 Q9NR22 2/20 0.54
▸ PRMT1 Q99873 1/20 0.47
▸ ALDH1A1 P00352 3/20 0.44
▸ KDM1A O60341 1/20 0.42
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36
▸ PTGS2 P35354 1/20 0.36
▸ CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14500308 0.82 ALDH1A1 (0.43) ALDH1A1KDM1AMEN1KMT2ATDP1
SCHEMBL1045046 0.80 CARM1 (0.79) CARM1PRMT6PRMT8PRMT1
SCHEMBL240714 0.80 — —
SCHEMBL12607000 0.79 MEN1 (0.44) CARM1PRMT6PRMT8ALDH1A1KDM1A
SCHEMBL16601547 0.79 CACNA1H (0.43) ALDH1A1KDM1AMEN1KMT2ATDP1
SCHEMBL4054338 0.79 ALDH1A1 (0.41) ALDH1A1KDM1AMEN1KMT2ATDP1
SCHEMBL23108394 0.79 TDP1 (0.39) ALDH1A1KDM1AMEN1KMT2ATDP1
SCHEMBL9836417 0.78 ALDH1A1 (0.52) ALDH1A1KDM1AMEN1KMT2ATDP1
SCHEMBL1098206 0.77 KDM1A (0.45) ALDH1A1KDM1AMEN1KMT2ATDP1
SCHEMBL10262951 0.77 MEN1 (0.46) ALDH1A1KDM1AMEN1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022255764-A1 NOVEL OXAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME FOR PREVENTION OR TREATMENT OF ALLERGIC DISEASE 주식회사 에즈큐리스 2022-12-08 — — WO disclosed
US-10329263-B2 Disubstituted 1, 2, 4-triazine compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-06-25 — — US disclosed
US-10029993-B2 Disubstituted 1, 2, 4-triazine compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2018-07-24 — — US disclosed
US-10029993-B2 Disubstituted 1, 2, 4-triazine compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2018-07-24 — — US disclosed
US-9637492-B2 Benzothiazole kinase inhibitors and methods of use INTELLIKINE LLC (US) 2017-05-02 — — US disclosed
US-20170044115-A1 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2017-02-16 — — US disclosed
US-20170044115-A1 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2017-02-16 — — US disclosed
US-20150225407-A1 Benzothiazole Kinase Inhibitors and Methods of Use INTELLIKINE LLC 2015-08-13 — — US disclosed
US-8993580-B2 Benzothiazole kinase inhibitors and methods of use INTELLIKINE LLC (US) 2015-03-31 — — US disclosed
US-8637542-B2 Kinase inhibitors and methods of use INTELLIKINE, INC. (US) 2014-01-28 — — US disclosed
WO-2013012915-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF INFINITY PHARMACEUTICALS INC. (US) 2013-01-24 — — WO disclosed
US-20110124641-A1 BENZOTHIAZOLE KINASE INHIBITORS AND METHODS OF USE INTELLIKINE LLC 2011-05-26 — — US disclosed
US-20080027037-A1 Cyclic compounds TANABE SEIYAKU CO., LTD. 2008-01-31 — — US disclosed
US-7273868-B2 Pyrazine derivatives TANABE SEIYAKU CO., LTD. (JP) 2007-09-25 — — US disclosed
US-7273868-B2 Pyrazine derivatives TANABE SEIYAKU CO., LTD. (JP) 2007-09-25 — — US disclosed
US-7220736-B2 Pyrimidine compounds TANABE SEIYAKU CO., LTD. (JP) 2007-05-22 — — US disclosed
US-7220736-B2 Pyrimidine compounds TANABE SEIYAKU CO., LTD. (JP) 2007-05-22 — — US disclosed
EP-0008696-B1 BASICALLY SUBSTITUTED UREA COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME Asta-Werke Aktiengesellschaft Chemische Fabrik (DE) 1982-12-15 — — EP disclosed
US-4239761-A VIRICIDES ASTA-WERKE AKTIENGESELLSCHAFT, CHEMISCHE FABRIK (DE) 1980-12-16 — — US disclosed
EP-0008696-A1 Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same Asta-Werke Aktiengesellschaft Chemische Fabrik (DE) 1980-03-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10329263-B2 Disubstituted 1, 2, 4-triazine compound NR3C2, REN, NR5A1 CARM1 912/4885PRMT6 2500/4885PRMT8 1976/4885
US-20170044115-A1 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND NR3C2, REN, CYP21A2 CARM1 1305/4885PRMT6 2900/4885PRMT8 2382/4885
US-20110124641-A1 BENZOTHIAZOLE KINASE INHIBITORS AND METHODS OF USE MTOR, PDPK1, PIKFYVE CARM1 1779/4885PRMT6 1421/4885PRMT8 1529/4885
US-10029993-B2 Disubstituted 1, 2, 4-triazine compound NR3C2, REN, NR5A1 CARM1 912/4885PRMT6 2500/4885PRMT8 1976/4885
US-20150225407-A1 Benzothiazole Kinase Inhibitors and Methods of Use MTOR, PDPK1, PIKFYVE CARM1 1779/4885PRMT6 1421/4885PRMT8 1529/4885
US-20080027037-A1 Cyclic compounds PDE4A, PDE4B, PDE3B CARM1 262/4885PRMT6 456/4885PRMT8 415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.