Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9283021 | 0.89 | HRH3 (0.56) | THRATHRBPLA2G10PLA2G2AHRH3 | |
| SCHEMBL1346949 | 0.84 | RARB (0.59) | THRATHRBLMNAKCNH2SIGMAR1 | |
| SCHEMBL9149170 | 0.84 | HSD17B10 (0.61) | THRATHRBLMNAKCNH2SIGMAR1 | |
| SCHEMBL11451779 | 0.82 | THRA (0.53) | THRATHRBLMNAKCNH2SIGMAR1 | |
| SCHEMBL24022357 | 0.81 | BCHE (0.50) | PLA2G10PLA2G2ASIGMAR1 | |
| SCHEMBL28049825 | 0.81 | THRA (0.63) | THRATHRBLMNAKCNH2SIGMAR1 | |
| SCHEMBL9670561 | 0.80 | SIGMAR1 (0.64) | LMNAKCNH2SIGMAR1HRH3HTR1A | |
| SCHEMBL607614 | 0.79 | RARB (0.62) | THRATHRBHSD17B10 | |
| SCHEMBL5068476 | 0.79 | CYP4A11 (0.68) | THRATHRBLMNAHSD17B10 | |
| SCHEMBL2677626 | 0.78 | RARB (0.64) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0047536-A2 | Substituted propylamines | ELI LILLY AND COMPANY (US) | 1982-03-17 | — | — | EP | claimed |
| EP-0047536-A2 | Substituted propylamines | ELI LILLY AND COMPANY (US) | 1982-03-17 | — | — | EP | disclosed |
| EP-0007206-A1 | Phenethanolamines, their formulations, preparation and use | ELI LILLY AND COMPANY (US) | 1980-01-23 | — | — | EP | disclosed |