Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11188355 | 0.87 | GAA (0.47) | OPRM1SLC6A4POLBOPRD1OPRK1 | |
| SCHEMBL11085421 | 0.86 | ALDH1A1 (0.40) | OPRM1SLC6A4SLC6A2OPRD1OPRK1 | |
| SCHEMBL11487502 | 0.85 | MEN1 (0.41) | OPRM1SLC6A4SLC6A2OPRD1OPRK1 | |
| SCHEMBL11541268 | 0.80 | OPRM1 (0.43) | OPRM1POLBGAAGRIN2DGRIN3B | |
| SCHEMBL7238616 | 0.73 | HTR7 (0.38) | OPRM1SLC6A4SLC6A2GAASLC22A1 | |
| SCHEMBL11493527 | 0.73 | FNTA (0.41) | OPRM1SLC6A4SLC6A2OPRD1OPRK1 | |
| SCHEMBL23595550 | 0.71 | LMNA (0.52) | OPRM1SLC6A4SLC6A2SLC22A1CHRM2 | |
| SCHEMBL23595542 | 0.71 | LMNA (0.52) | OPRM1SLC6A4SLC6A2SLC22A1CHRM2 | |
| SCHEMBL9316420 | 0.71 | CYP3A4 (0.42) | OPRM1SLC6A4OPRD1OPRK1GAA | |
| SCHEMBL7679805 | 0.69 | FNTA (0.44) | OPRM1SLC6A4SLC6A2OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337341-A | 4a-Aryl-octahydro-1H-2-pyrindines | ELI LILLY AND COMPANY (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0002937-A1 | Novel pyrindines and their preparation, formulations and use | ELI LILLY AND COMPANY (US) | 1979-07-11 | — | — | EP | disclosed |