SCHEMBL11250322

SCHEMBL11250322

CN(C)C(=O)N(N)c1ccc(F)c(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.51
TSHR P16473 3/20 0.39
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
KMT2A Q03164 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
HTT P42858 2/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
SLC2A1 P11166 1/20 0.37
POLQ O75417 2/20 0.37
IDO1 P14902 1/20 0.37
MAPT P10636 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11724538 0.98 ALDH1A1 (0.50) ALDH1A1TSHRNPC1RAB9AKMT2A
SCHEMBL11257421 0.85 APEX1 (0.45) ALDH1A1TSHRLMNA
SCHEMBL11250175 0.85 CES2 (0.38) ALDH1A1KMT2AHTTMEN1
Hydrochloric Acid SCHEMBL11639231 0.83 APEX1 (0.44) ALDH1A1TSHRLMNA
SCHEMBL11268173 0.81 MEN1 (0.41) ALDH1A1NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL9638977 0.79 ALDH1A1 (0.44) ALDH1A1TSHRRAB9AHTTMAPT
SCHEMBL11259916 0.79 TSHR (0.42) ALDH1A1TSHRNPC1RAB9AKMT2A
SCHEMBL11248074 0.78 ALDH1A1 (0.36) ALDH1A1KMT2AHTTMEN1MAPT
SCHEMBL11253602 0.78 ALDH1A1 (0.40) ALDH1A1NPC1RAB9AKMT2ASMN1; SMN2
Hydrochloric Acid SCHEMBL11720486 0.77 HDAC8 (0.41) POLQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4358611-A FROM A PHENYLHYDRAZINE, A CHLOROFORMATE, PHOSGENE AND A SECONDARY AMINE SHELL OIL COMPANY (US) 1982-11-09 US claimed
US-4358611-A FROM A PHENYLHYDRAZINE, A CHLOROFORMATE, PHOSGENE AND A SECONDARY AMINE SHELL OIL COMPANY (US) 1982-11-09 US disclosed
US-4108399-A Herbicidal semicarbazones SHELL OIL COMPANY (US) 1978-08-22 US disclosed
US-4099956-A Herbicidal semicarbazones SHELL OIL COMPANY (US) 1978-07-11 US disclosed
US-4050918-A Herbicidal semicarbazides SHELL OIL COMPANY (US) 1977-09-27 US disclosed
US-3984463-A Herbicidal 2-phenyl semicarbazides SHELL OIL COMPANY (US) 1976-10-05 US disclosed