Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 6/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261476 | 0.90 | OPRK1 (0.45) | PIK3C3TP53SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL11341931 | 0.85 | CCKBR (0.37) | LRRK2 | |
| SCHEMBL11251237 | 0.85 | CCKBR (0.40) | PIK3C3GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11262891 | 0.83 | GABRA1 (0.46) | PIK3C3ALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL11262982 | 0.78 | PIK3C3 (0.36) | PIK3C3ALDH1A1MAPTHPGDGABRA1 | |
| SCHEMBL11258077 | 0.76 | OPRK1 (0.51) | TP53HPGDGABRA1GABRA5GABRA2 | |
| SCHEMBL11259753 | 0.74 | GABRA1 (0.41) | LRRK2NPC1TSHRGABRA1GABRA5 | |
| SCHEMBL11255309 | 0.74 | OPRK1 (0.38) | PIK3C3TP53HPGDGABRA1GABRA5 | |
| SCHEMBL11259584 | 0.71 | OPRK1 (0.36) | PIK3C3LRRK2ALDH1A1MAPTHPGD | |
| SCHEMBL11250610 | 0.71 | CHRM1 (0.36) | PIK3C3ALDH1A1TP53MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4338314-A | [1,2]Anellated-7-phenyl-1,4-benzodiazepine and pharmaceutical compositions thereof and use for treatment of ulcers | KALI-CHEMIE PHARMA GMBH (DE) | 1982-07-06 | — | — | US | disclosed |
| EP-0008045-B1 | (1,2)-ANNELLATED 7-PHENYL-1,4-BENZODIAZEPINE DERIVATIVES AND SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Kali-Chemie Pharma GmbH (DE) | 1981-09-30 | — | — | EP | disclosed |
| EP-0008045-A1 | (1,2)-Annellated 7-phenyl-1,4-benzodiazepine derivatives and salts thereof, processes for their preparation and medicaments containing them | Kali-Chemie Pharma GmbH (DE) | 1980-02-20 | — | — | EP | disclosed |