Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261987 | 0.84 | OPRK1 (0.38) | OPRK1NR1I2ADORA3HTR2CADRA1A | |
| SCHEMBL11250610 | 0.84 | CHRM1 (0.36) | OPRK1NR1I2ADORA3HTR2CADRA1A | |
| SCHEMBL11258077 | 0.84 | OPRK1 (0.51) | OPRK1NR1I2ADORA3HTR2CADRA1A | |
| SCHEMBL11251237 | 0.81 | CCKBR (0.40) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11259584 | 0.79 | OPRK1 (0.36) | OPRK1NR1I2ADORA3HTR2CADRA1A | |
| SCHEMBL11259156 | 0.79 | KDM4E (0.38) | PDE4DTP53LMNAHPGD | |
| Maleic Acid SCHEMBL11253030 | 0.77 | OPRK1 (0.44) | OPRK1NR1I2ADORA3HTR2CADRA1A | |
| SCHEMBL11261751 | 0.75 | LMNA (0.52) | OPRK1PDE4DGABRA1GABRA5GABRA3 | |
| SCHEMBL11261476 | 0.74 | OPRK1 (0.45) | OPRK1NR1I2ADORA3HTR2CADRA1A | |
| SCHEMBL11253227 | 0.74 | PIK3C3 (0.40) | TP53GABRA1GABRA5GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4338314-A | [1,2]Anellated-7-phenyl-1,4-benzodiazepine and pharmaceutical compositions thereof and use for treatment of ulcers | KALI-CHEMIE PHARMA GMBH (DE) | 1982-07-06 | — | — | US | disclosed |
| EP-0008045-B1 | (1,2)-ANNELLATED 7-PHENYL-1,4-BENZODIAZEPINE DERIVATIVES AND SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Kali-Chemie Pharma GmbH (DE) | 1981-09-30 | — | — | EP | disclosed |
| EP-0008045-A1 | (1,2)-Annellated 7-phenyl-1,4-benzodiazepine derivatives and salts thereof, processes for their preparation and medicaments containing them | Kali-Chemie Pharma GmbH (DE) | 1980-02-20 | — | — | EP | disclosed |