Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SELPLG | Q14242 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256929 | 0.88 | RAB9A (0.40) | LMNATRPV1CYP3A4DHODH | |
| SCHEMBL11259590 | 0.87 | TRPV1 (0.37) | SELPLGCXCL8TRPV1CYP3A4CYP2C9 | |
| SCHEMBL11257836 | 0.87 | BCHE (0.41) | CSNK2A2CSNK2BPDE3BPDE3ADHODH | |
| SCHEMBL11257378 | 0.85 | MMP2 (0.48) | PDE3BPDE3ALMNA | |
| SCHEMBL11257643 | 0.85 | PSEN1 (0.39) | LMNACYP3A4CYP2C9 | |
| SCHEMBL11263420 | 0.85 | HSP90AA1 (0.37) | CXCL8TRPV1 | |
| SCHEMBL11439308 | 0.81 | CXCL8 (0.46) | CXCL8CYP3A4CYP2C9 | |
| SCHEMBL11254442 | 0.78 | KDM4E (0.38) | — | |
| SCHEMBL11260467 | 0.78 | TDO2 (0.42) | SELPLGCSNK2A2CSNK2BIDO1TDO2 | |
| SCHEMBL298816 | 0.76 | CYP2A6 (0.40) | TDO2CXCL8CYP3A4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |