Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | FADS1 | O60427 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11240075 | 0.87 | EGFR (0.53) | EGFRGALR3NR2F2NPC1RAB9A | |
| SCHEMBL11248882 | 0.87 | EGFR (0.52) | EGFRFADS1LCKGALR3NR2F2 | |
| SCHEMBL11256846 | 0.86 | NR2F2 (0.59) | EGFRGALR3NR2F2NPC1RAB9A | |
| SCHEMBL11250025 | 0.81 | NPC1 (0.52) | EGFRGALR3NR2F2NPC1RAB9A | |
| SCHEMBL11255628 | 0.80 | GBA1 (0.56) | EGFRGALR3NR2F2NPC1RAB9A | |
| SCHEMBL28673063 | 0.79 | EGFR (0.46) | EGFRFADS1LCKTP53GALR3 | |
| SCHEMBL29898270 | 0.79 | EGFR (0.46) | EGFRFADS1LCKTP53GALR3 | |
| SCHEMBL11246634 | 0.79 | SMN1; SMN2 (0.51) | EGFRGALR3NR2F2NPC1RAB9A | |
| SCHEMBL11254153 | 0.79 | LDHA (0.61) | EGFRTP53GALR3NR2F2NPC1 | |
| SCHEMBL11259342 | 0.78 | MAP4K4 (0.55) | EGFRFADS1LCKNR2F2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |