Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.49 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28191294 | 0.82 | IMPDH2 (0.45) | IMPDH2LMNAPDGFRAMAPK8CDK5 | |
| SCHEMBL28435895 | 0.81 | CDK4 (0.47) | IMPDH2CDK4CCND1LMNAPDGFRA | |
| SCHEMBL7042649 | 0.81 | ESR1 (0.56) | IMPDH2IMPDH1CDK4CCND1ESR1 | |
| SCHEMBL30736499 | 0.79 | TUBB4A (0.43) | IMPDH2LMNAPDGFRAMAPK8CDK5 | |
| SCHEMBL933915 | 0.76 | HTR2A (0.54) | IMPDH2IMPDH1HTR2AHTR2CMAPT | |
| SCHEMBL17383846 | 0.72 | IMPDH2 (0.73) | IMPDH2HTR2AHTR2CLMNAESR1 | |
| Chloroform SCHEMBL11530972 | 0.70 | HTR2A (0.49) | IMPDH2IMPDH1HTR2AHTR2CMAPT | |
| SCHEMBL8912928 | 0.70 | HTR2A (0.65) | IMPDH2IMPDH1HTR2AHTR2CMAPT | |
| SCHEMBL3886120 | 0.70 | IMPDH2 (0.71) | IMPDH2IMPDH1HTR2AHTR2CCDK4 | |
| SCHEMBL933390 | 0.69 | HTR2A (0.51) | IMPDH2IMPDH1HTR2AHTR2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |