Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 14/20 | 0.48 |
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.46 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL29945132 | 1.00 | HTR2A (0.48) | HTR2AHRH1HTR2CGAAMAPT | |
| Fumaric Acid SCHEMBL5367297 | 1.00 | HTR2A (0.48) | HTR2AHRH1HTR2CGAAMAPT | |
| SCHEMBL5365272 | 0.87 | HTR2A (0.59) | HTR2AHRH1HTR2CSLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL11248605 | 0.87 | HTR2A (0.45) | HTR2AHRH1HTR2CGAAMAPT | |
| Fumaric Acid SCHEMBL11248576 | 0.87 | HTR2A (0.45) | HTR2AHRH1HTR2CGAAMAPT | |
| SCHEMBL4667774 | 0.78 | HSD17B10 (0.52) | HTR2AHRH1HTR2CGAAMAPT | |
| Fumaric Acid SCHEMBL11102655 | 0.77 | GRM1 (0.39) | HTR2AHTR2CGAAMAPTLMNA | |
| Fumaric Acid SCHEMBL11246801 | 0.77 | GRM1 (0.39) | HTR2AHTR2CGAAMAPTLMNA | |
| SCHEMBL5367303 | 0.76 | HTR2A (0.36) | HTR2AHRH1HTR2CGAAMAPT | |
| SCHEMBL5367301 | 0.76 | HTR2A (0.36) | HTR2AHRH1HTR2CGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313931-A | ANTIHISTAMINES, ANTISEROTONINE AGENTS, ANTIALLERGENS, BRONCHODILATOR AGENTS, ANTIANAPHYLACTIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 1982-02-02 | — | — | US | disclosed |