Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | FDPS | P14324 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256995 | 1.00 | TSHR (0.63) | TSHRNPSR1BLMMAPK1ACHE | |
| SCHEMBL187138 | 0.87 | NPSR1 (0.75) | TSHRNPSR1BLMMAPK1ACHE | |
| SCHEMBL187137 | 0.87 | NPSR1 (0.75) | TSHRNPSR1BLMMAPK1ACHE | |
| SCHEMBL7436823 | 0.84 | TSHR (0.58) | TSHRNPSR1BLMACHEALDH1A1 | |
| SCHEMBL30112581 | 0.83 | TSHR (0.69) | TSHRNPSR1BLMACHEALDH1A1 | |
| SCHEMBL974152 | 0.83 | TSHR (0.69) | TSHRNPSR1BLMACHEALDH1A1 | |
| SCHEMBL974150 | 0.83 | TSHR (0.69) | TSHRNPSR1BLMACHEALDH1A1 | |
| SCHEMBL29350145 | 0.83 | TSHR (0.69) | TSHRNPSR1BLMACHEALDH1A1 | |
| SCHEMBL5133590 | 0.82 | NPSR1 (0.49) | TSHRNPSR1BLMSMN1; SMN2 | |
| SCHEMBL28441888 | 0.82 | TSHR (0.68) | TSHRNPSR1BLMACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4333877-A | Substituted 2,7-dioxo-2,7-dihydrobenzo[1:2-b; 5:6-b1 ]difuran or -dipyrrole dyestuffs, their preparation and their use | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-06-08 | — | — | US | disclosed |
| EP-0023080-A1 | Substituted 2,7-dioxo-2,7-dihydrobenzo(1:2-b; 5,6-b1)difuran or dipyrrole dyestuffs, processes for their preparation and their use for the colouration of aromatic polyester textile materials | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-01-28 | — | — | EP | disclosed |