Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487824 | 0.90 | ALDH1A1 (0.58) | ALDH1A1TSHRKMT2AMAPTMEN1 | |
| SCHEMBL11253338 | 0.85 | ALDH1A1 (0.76) | ALDH1A1TSHRKMT2AMAPTMEN1 | |
| SCHEMBL7734714 | 0.85 | ALDH1A1 (0.81) | ALDH1A1TSHRKMT2AMAPTMEN1 | |
| SCHEMBL11262526 | 0.85 | LMNA (0.73) | ALDH1A1TSHRKMT2AMAPTMEN1 | |
| SCHEMBL11263773 | 0.84 | MEN1 (0.72) | ALDH1A1TSHRKMT2AMAPTMEN1 | |
| SCHEMBL11258740 | 0.84 | ALDH1A1 (0.74) | ALDH1A1TSHRKMT2AMAPTMEN1 | |
| SCHEMBL11264725 | 0.82 | APEX1 (0.64) | KMT2AMEN1SMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL1857784 | 0.81 | VDR (0.50) | ALDH1A1KMT2AMAPTMEN1GAA | |
| SCHEMBL7740712 | 0.79 | ALDH1A1 (0.66) | ALDH1A1TSHRKMT2AMAPTMEN1 | |
| SCHEMBL11266490 | 0.79 | ALDH1A1 (0.69) | ALDH1A1TSHRKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019440-B1 | BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| EP-0019440-A1 | Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them | PFIZER INC. (US) | 1980-11-26 | — | — | EP | disclosed |
| US-4209527-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |