Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254480 | 0.84 | MEN1 (0.54) | ALDH1A1MAPTGAASMN1; SMN2HSD17B10 | |
| SCHEMBL11261064 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MAPTGAASMN1; SMN2POLB | |
| SCHEMBL30444127 | 0.76 | TACR3 (0.40) | ALDH1A1MAPTALOX12GAATP53 | |
| SCHEMBL25256653 | 0.74 | MAPK11 (0.43) | ALDH1A1MAPTALOX12GAATP53 | |
| SCHEMBL3036220 | 0.74 | ALDH1A1 (0.58) | ALDH1A1MAPTGAAPOLBHPGD | |
| SCHEMBL31560228 | 0.74 | HSD11B1 (0.38) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL11266599 | 0.69 | BCHE (0.58) | ALDH1A1SMN1; SMN2POLBBCHEKMT2A | |
| SCHEMBL425308 | 0.69 | POLB (0.58) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL8877725 | 0.69 | L3MBTL1 (0.69) | ALDH1A1SMN1; SMN2HSD17B10KMT2AMEN1 | |
| SCHEMBL11252258 | 0.67 | USP2 (0.47) | ALDH1A1MAPTALOX12GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309541-A | CHEMICAL INTERMEDIATES TO QUINAZOLINE HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4255429-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| EP-0009465-A1 | N-(1-(4-amino-2-quinazolinyl)-3 or 4-piperidyl lactames, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-04-02 | — | — | EP | disclosed |