Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400125 | 0.91 | POLB (0.45) | POLBTSHRKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23857686 | 0.81 | PDE4A (0.41) | POLBTSHRKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9458900 | 0.77 | THRB (0.43) | POLBKMT2ASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL29068053 | 0.76 | POLB (0.54) | POLBTSHRKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2526110 | 0.76 | HTT (0.41) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4523217 | 0.75 | SLC6A1 (0.44) | POLBTSHRKMT2ASMN1; SMN2TDP1 | |
| SCHEMBL8414225 | 0.75 | POLB (0.41) | POLBKMT2ASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL567871 | 0.75 | SLC6A1 (0.44) | POLBTSHRKMT2ASMN1; SMN2TDP1 | |
| SCHEMBL2446601 | 0.75 | SLC6A1 (0.44) | POLBTSHRKMT2ASMN1; SMN2TDP1 | |
| SCHEMBL1439129 | 0.75 | TDP1 (0.48) | POLBKMT2AALDH1A1TDP1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4345071-A | AZIDOALKYL-HETEROCYCLIC AMIDINE INTERMEDIATES | LEO PHARMACEUTICAL PRODUCTS, LTD. A/S (DK) | 1982-08-17 | — | — | US | disclosed |
| US-4229443-A | Derivatives of penicillanic acid | LEO PHARMACEUTICAL PRODUCTS, LTD. A/S (DK) | 1980-10-21 | — | — | US | disclosed |