Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11051530 | 0.82 | GAA (0.50) | POLBALDH1A1ALOX12CYP1A2CYP3A4 | |
| SCHEMBL5520683 | 0.81 | DRD2 (0.59) | POLBALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5222474 | 0.81 | GRIN2D (0.55) | POLBALDH1A1ALOX12CYP1A2DRD2 | |
| SCHEMBL15484311 | 0.80 | LMNA (0.69) | POLBALDH1A1ALOX12CYP1A2CYP3A4 | |
| SCHEMBL6692615 | 0.79 | DRD2 (0.54) | POLBALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11054164 | 0.79 | GAA (0.50) | CYP1A2GAA | |
| SCHEMBL27709153 | 0.78 | POLB (0.55) | POLBALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11258013 | 0.78 | EPHX1 (0.72) | ALDH1A1ALOX12CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8721848 | 0.78 | POLB (0.53) | POLBALDH1A1ALOX12CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11258555 | 0.77 | PKM (0.55) | POLBALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4025652-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1977-05-24 | — | — | US | disclosed |