Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11285948 | 0.88 | NR1H2 (0.42) | TDP1PTGDR2PPARGNR1H2NR1H3 | |
| SCHEMBL11246786 | 0.86 | LMNA (0.48) | TDP1PTGDR2PPARGNR1H2NR1H3 | |
| SCHEMBL11251835 | 0.85 | TDP1 (0.54) | TDP1PTGDR2PPARGNR1H2NR1H3 | |
| SCHEMBL11252609 | 0.85 | PKM (0.39) | TDP1KDM4EMAPTLMNAPOLB | |
| SCHEMBL11255704 | 0.83 | PTGDR2 (0.49) | TDP1PTGDR2KDM4ECYP1A2MAPT | |
| SCHEMBL11261678 | 0.83 | TDP1 (0.45) | TDP1PTGDR2PPARGNR1H2NR1H3 | |
| SCHEMBL11262804 | 0.83 | TDP1 (0.45) | TDP1PTGDR2KDM4ECYP1A2MAPT | |
| SCHEMBL11258880 | 0.82 | MMP2 (0.51) | TDP1PTGDR2KDM4E | |
| SCHEMBL11250186 | 0.82 | PTGDR2 (0.43) | TDP1PTGDR2PPARGNR1H2NR1H3 | |
| SCHEMBL11246793 | 0.80 | PPARD (0.47) | TDP1PTGDR2PPARGNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |