Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 4/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 3/20 | 0.37 |
| ▸ | PLG | P00747 | 3/20 | 0.37 |
| ▸ | PLAT | P00750 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11086646 | 0.90 | HTT (0.44) | L3MBTL1HTTTSHRALDH1A1MAPT | |
| SCHEMBL11579665 | 0.86 | KMT2A (0.36) | HTTALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL11248653 | 0.85 | HTT (0.55) | L3MBTL1HTTTSHRALDH1A1MAPT | |
| SCHEMBL11264201 | 0.85 | LMNA (0.41) | L3MBTL1HTTTSHRALDH1A1MAPT | |
| SCHEMBL11580892 | 0.85 | SLC2A1 (0.36) | L3MBTL1HTTALDH1A1MAPTKMT2A | |
| SCHEMBL11436815 | 0.83 | HTT (0.40) | L3MBTL1HTTTSHRALDH1A1MAPT | |
| SCHEMBL11049539 | 0.82 | HTT (0.49) | L3MBTL1HTTTSHRALDH1A1MAPT | |
| SCHEMBL11579652 | 0.80 | CYP1A2 (0.36) | ALDH1A1RAB9ANPC1SMN1; SMN2F2 | |
| SCHEMBL11266319 | 0.80 | HTT (0.39) | L3MBTL1HTTTSHRALDH1A1MAPT | |
| SCHEMBL11097728 | 0.77 | CYP1A2 (0.36) | HTTTSHRMAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |