Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11409212 | 0.88 | RAPGEF4 (0.42) | LMNARAPGEF4ALDH1A1F2F10 | |
| SCHEMBL11262024 | 0.85 | L3MBTL1 (0.40) | LMNAALDH1A1F2F10PLG | |
| SCHEMBL11093189 | 0.83 | LMNA (0.37) | LMNARAPGEF4ALDH1A1PKM | |
| SCHEMBL11279846 | 0.82 | LMNA (0.41) | LMNARAPGEF4ALDH1A1F2F10 | |
| SCHEMBL11248653 | 0.82 | HTT (0.55) | LMNARAPGEF4ALDH1A1L3MBTL1HTT | |
| SCHEMBL11057173 | 0.81 | LCK (0.43) | LMNARAPGEF4ALDH1A1L3MBTL1HTT | |
| SCHEMBL11578513 | 0.79 | ALDH1A1 (0.36) | ALDH1A1F2PLGHTTMAPT | |
| SCHEMBL11579586 | 0.79 | DRD2 (0.44) | ALDH1A1F2F10PLGPLAU | |
| SCHEMBL11095766 | 0.77 | P2RX1 (0.39) | RAPGEF4ALDH1A1MAPT | |
| SCHEMBL11266319 | 0.77 | HTT (0.39) | LMNARAPGEF4ALDH1A1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |