Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248653 | 0.92 | HTT (0.55) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11262024 | 0.90 | L3MBTL1 (0.40) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11097728 | 0.87 | CYP1A2 (0.36) | HTTTSHRMAPTKMT2APLAU | |
| SCHEMBL11091737 | 0.86 | ALDH1A1 (0.40) | HTTALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL11839381 | 0.86 | HTT (0.39) | HTTTSHRALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL11837045 | 0.85 | HTT (0.38) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11579652 | 0.83 | CYP1A2 (0.36) | ALDH1A1RAB9ACYP1A2 | |
| SCHEMBL11580765 | 0.83 | CYP1A2 (0.36) | PLAUCYP1A2 | |
| SCHEMBL11251379 | 0.83 | CYP1A2 (0.36) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11096378 | 0.83 | RAPGEF4 (0.42) | HTTTSHRALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | disclosed |
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |