SCHEMBL11262545

SCHEMBL11262545

Cc1cc(N(N)C(=O)N(C)C)ccc1Br

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.35
RAB9A P51151 7/20 0.35
NPC1 O15118 5/20 0.35
MAPT P10636 3/20 0.34
CHRNA1 P02708 1/20 0.34
CHRNG P07510 1/20 0.34
CHRNB1 P11230 1/20 0.34
CHRNB2 P17787 1/20 0.34
SLC6A2 P23975 1/20 0.34
CHRNB4 P30926 1/20 0.34
SLC6A4 P31645 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA4 P43681 1/20 0.34
SLC6A3 Q01959 1/20 0.34
CHRND Q07001 1/20 0.34
ALOX12 P18054 1/20 0.34
HTT P42858 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
KMT2A Q03164 3/20 0.33
IDO1 P14902 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11268173 0.82 MEN1 (0.41) ALDH1A1RAB9ANPC1MAPTALOX12
SCHEMBL11247372 0.77 MAPT (0.41) ALDH1A1RAB9AMAPTHTTKMT2A
SCHEMBL850628 0.74 ALDH1A1 (0.46) ALDH1A1RAB9ANPC1MAPTCHRNA1
SCHEMBL18556032 0.74 RAB9A (0.43) ALDH1A1RAB9ANPC1MAPTCHRNA1
SCHEMBL11262550 0.73 PDE5A (0.35) ALDH1A1RAB9ANPC1MAPTHTT
SCHEMBL11257421 0.72 APEX1 (0.45) ALDH1A1SLC6A2SLC6A4SLC6A3LMNA
SCHEMBL11250175 0.72 CES2 (0.38) ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL1883344 0.72 MAPT (0.47) ALDH1A1RAB9ANPC1MAPTKMT2A
Hydrochloric Acid SCHEMBL11639231 0.71 APEX1 (0.44) ALDH1A1SLC6A2SLC6A4SLC6A3LMNA
SCHEMBL9638977 0.69 ALDH1A1 (0.44) ALDH1A1RAB9AMAPTALOX12HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4358611-A FROM A PHENYLHYDRAZINE, A CHLOROFORMATE, PHOSGENE AND A SECONDARY AMINE SHELL OIL COMPANY (US) 1982-11-09 US disclosed