Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 6/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.38 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.40 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11256148 | 0.94 | SLC6A1 (0.44) | ALDH1A1SLC6A1SLC6A12SLC6A11SCN1A | |
| SCHEMBL11251756 | 0.92 | SLC6A1 (0.46) | ALDH1A1SLC6A1SLC6A12SLC6A11SCN1A | |
| SCHEMBL11241358 | 0.86 | SLC6A1 (0.50) | ALDH1A1SLC6A1SLC6A12SLC6A11CHRM2 | |
| SCHEMBL11257896 | 0.82 | SLC6A1 (0.56) | SLC6A1SLC6A12SLC6A11SCN1ASCN2A | |
| SCHEMBL7780678 | 0.82 | SLC6A1 (0.56) | SLC6A1SLC6A12SLC6A11SCN1ASCN2A | |
| SCHEMBL11253836 | 0.79 | SLC6A1 (0.45) | SLC6A1SLC6A12SLC6A11SCN1ASCN2A | |
| Fumaric Acid SCHEMBL11257527 | 0.78 | SLC6A1 (0.40) | ALDH1A1SLC6A1SLC6A12SLC6A11HRH1 | |
| Ramciclane SCHEMBL2108206 | 0.78 | SLC6A1 (0.64) | SLC6A1SLC6A12SLC6A11SCN1ASCN2A | |
| SCHEMBL11245908 | 0.77 | SLC6A1 (0.45) | SLC6A1SLC6A12SLC6A11CHRM2CHRM1 | |
| SCHEMBL11252330 | 0.75 | SLC6A1 (0.49) | SLC6A1SLC6A12SLC6A11CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4342762-A | USEFUL AS TRANQUILIZERS, ANALGESICS, ANTIEPILEPTIC AGENTS, AND AS A TREATMENT FOR PARKINSON'S DISEASE | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1982-08-03 | — | — | US | disclosed |