Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.55 |
| ▸ | DRD3 | P35462 | 4/20 | 0.55 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489608 | 0.87 | DRD2 (0.42) | DRD2DRD4DRD3HTR1DSIGMAR1 | |
| SCHEMBL11268179 | 0.84 | DRD2 (0.50) | DRD2DRD4DRD3HTR1AFYN | |
| SCHEMBL11269661 | 0.82 | SIGMAR1 (0.42) | DRD2DRD4DRD3HTR1DSIGMAR1 | |
| SCHEMBL11498936 | 0.80 | DRD2 (0.37) | DRD2DRD4DRD3HTR1DSIGMAR1 | |
| SCHEMBL11267287 | 0.78 | HTR1A (0.64) | DRD2DRD4DRD3HTR1DHTR1A | |
| SCHEMBL12125968 | 0.77 | DRD3 (0.65) | DRD2DRD4DRD3HTR1A | |
| Maleic Acid SCHEMBL11269870 | 0.74 | ALDH1A1 (0.43) | DRD2DRD4DRD3HTR1AFYN | |
| Hydrochloric Acid SCHEMBL11207856 | 0.73 | DRD2 (0.46) | DRD2DRD4DRD3HTR1DSIGMAR1 | |
| SCHEMBL26297471 | 0.72 | DRD2 (0.62) | DRD2DRD4DRD3HTR1DSIGMAR1 | |
| SCHEMBL11266620 | 0.72 | DRD2 (0.49) | DRD2DRD4DRD3HTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014792-B1 | TETRAHYDRO-2H-BENZO(C)PYRROLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE AS THERAPEUTICALS | ELI LILLY AND COMPANY (US) | 1982-12-01 | — | — | EP | disclosed |
| US-4264622-A | TREATMENT OF PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4235776-A | USED FOR TREATMENT OF PARKINSON'S DISEASE, PROLACTIN INHIBITORS, AND DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |