Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 9/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.60 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11265279 | 0.94 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10629894 | 0.88 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7264142 | 0.88 | GABRG2 (0.79) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7328484 | 0.86 | GABRG2 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7304650 | 0.86 | GABRG2 (0.76) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8768403 | 0.86 | GABRG2 (0.76) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10811227 | 0.86 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10805526 | 0.86 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10808364 | 0.86 | GABRG2 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11258423 | 0.85 | GABRG2 (0.61) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353827-A | ANTICONVULSIVE, ANXIOLYTIC | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | claimed |
| US-4353827-A | ANTICONVULSIVE, ANXIOLYTIC | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | disclosed |