Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11271918 | 0.85 | MMP2 (0.49) | PDE3BPDE3ACLK1TLR9TLR8 | |
| Water SCHEMBL11275606 | 0.84 | MMP2 (0.48) | PDE3BPDE3ACLK1TLR9TLR8 | |
| SCHEMBL11269561 | 0.81 | CYP3A4 (0.44) | PDE3BPDE3ACLK1TLR9TLR8 | |
| SCHEMBL11273096 | 0.80 | CYP2D6 (0.54) | PDE3BPDE3ACLK1TLR9TLR8 | |
| SCHEMBL11221691 | 0.79 | PDE3B (0.49) | PDE3BPDE3ACLK1MMP2MMP13 | |
| SCHEMBL11270335 | 0.78 | CYP3A4 (0.48) | PDE3BPDE3ACLK1TLR9TLR8 | |
| SCHEMBL31265084 | 0.76 | MMP2 (0.49) | PDE3BPDE3ACLK1MMP2MMP13 | |
| SCHEMBL17493786 | 0.76 | PDE3B (0.49) | PDE3BPDE3ACLK1MMP2MMP13 | |
| SCHEMBL16848371 | 0.76 | JAK2 (0.50) | PDE3BPDE3ACLK1AAK1JAK2 | |
| SCHEMBL11269149 | 0.76 | PDE3B (0.49) | PDE3BPDE3ACLK1MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |