Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087533 | 0.86 | ALDH1A1 (0.37) | ALDH1A1MEN1TSHRCASP1KMT2A | |
| SCHEMBL11095711 | 0.78 | CYP3A4 (0.40) | ALDH1A1MEN1TSHRKMT2AMAPT | |
| SCHEMBL11089455 | 0.75 | ALDH1A1 (0.38) | ALDH1A1MEN1TSHRKMT2AMAPT | |
| SCHEMBL11260058 | 0.74 | KCNA5 (0.43) | ALDH1A1MAPTGAAKCNA5KCNH2 | |
| SCHEMBL11092419 | 0.72 | ALDH1A1 (0.41) | ALDH1A1MEN1TSHRKMT2AMAPT | |
| SCHEMBL11381103 | 0.66 | KCNA5 (0.40) | ALDH1A1TSHRMAPTL3MBTL1GAA | |
| SCHEMBL11375095 | 0.61 | CYP3A4 (0.39) | ALDH1A1MEN1TSHRKMT2AUSP2 | |
| SCHEMBL11251478 | 0.60 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1KCNA5 | |
| SCHEMBL11627896 | 0.60 | TSHR (0.40) | ALDH1A1MEN1TSHRKMT2AL3MBTL1 | |
| SCHEMBL11381545 | 0.58 | POLB (0.39) | ALDH1A1MEN1TSHRKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |