Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095711 | 0.92 | CYP3A4 (0.40) | ALDH1A1MAPTGAAL3MBTL1MEN1 | |
| SCHEMBL11089455 | 0.89 | ALDH1A1 (0.38) | ALDH1A1MAPTGAAL3MBTL1MEN1 | |
| SCHEMBL11092419 | 0.86 | ALDH1A1 (0.41) | ALDH1A1MAPTGAAL3MBTL1MEN1 | |
| SCHEMBL11266308 | 0.86 | ALDH1A1 (0.34) | ALDH1A1MAPTGAAL3MBTL1MEN1 | |
| SCHEMBL11093127 | 0.79 | MEN1 (0.34) | ALDH1A1MAPTMEN1KMT2ATSHR | |
| SCHEMBL11090519 | 0.78 | CYP3A4 (0.34) | ALDH1A1MAPTMEN1KMT2ATSHR | |
| SCHEMBL11260058 | 0.77 | KCNA5 (0.43) | ALDH1A1MAPTGAAKDM4EALOX12 | |
| SCHEMBL11625289 | 0.68 | KDM4E (0.43) | ALDH1A1MAPTGAAL3MBTL1TSHR | |
| SCHEMBL11381103 | 0.67 | KCNA5 (0.40) | ALDH1A1MAPTGAAL3MBTL1TSHR | |
| SCHEMBL11157410 | 0.67 | GAA (0.43) | ALDH1A1MAPTGAAL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486431-A | Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1984-12-04 | — | — | US | disclosed |