Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LDHA | P00338 | 2/20 | 0.34 |
| ▸ | LDHB | P07195 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095711 | 0.91 | CYP3A4 (0.40) | ALDH1A1MAPTL3MBTL1GAAHSD17B10 | |
| SCHEMBL11093127 | 0.90 | MEN1 (0.34) | ALDH1A1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL11090519 | 0.89 | CYP3A4 (0.34) | ALDH1A1MAPTHSD17B10KDM4EMEN1 | |
| SCHEMBL11092419 | 0.89 | ALDH1A1 (0.41) | ALDH1A1MAPTL3MBTL1GAAMEN1 | |
| SCHEMBL11087533 | 0.89 | ALDH1A1 (0.37) | ALDH1A1MAPTL3MBTL1GAAHSD17B10 | |
| SCHEMBL11260058 | 0.88 | KCNA5 (0.43) | ALDH1A1MAPTGAAHSD17B10KDM4E | |
| SCHEMBL11266308 | 0.75 | ALDH1A1 (0.34) | ALDH1A1MAPTL3MBTL1GAAHSD17B10 | |
| SCHEMBL11157410 | 0.69 | GAA (0.43) | ALDH1A1MAPTL3MBTL1GAAKDM4E | |
| SCHEMBL11203944 | 0.69 | ALDH1A1 (0.42) | ALDH1A1GAAMEN1KMT2ACYP1A2 | |
| SCHEMBL11625289 | 0.66 | KDM4E (0.43) | ALDH1A1MAPTL3MBTL1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486431-A | Cardiotonic use of 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1984-12-04 | — | — | US | disclosed |
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |