Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.57 |
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | HTR2A | P28223 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | HRH2 | P25021 | 1/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | TACR1 | P25103 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267488 | 0.91 | HTR1A (0.51) | HTR1ASIGMAR1DRD2HTR2AKDM4E | |
| SCHEMBL11264673 | 0.83 | KDM4E (0.51) | HTR1ASIGMAR1DRD2HTR2AKDM4E | |
| SCHEMBL4865321 | 0.79 | DRD2 (0.59) | HTR1ASIGMAR1DRD2HTR2AKDM4E | |
| SCHEMBL30767207 | 0.79 | HTR1A (0.80) | HTR1ASIGMAR1DRD2HTR2AKDM4E | |
| Hydrochloric Acid SCHEMBL30945326 | 0.78 | KDM4E (0.81) | HTR1ASIGMAR1DRD2HTR2AKDM4E | |
| SCHEMBL11262256 | 0.77 | DRD2 (0.62) | HTR1ASIGMAR1DRD2HTR2AKDM4E | |
| SCHEMBL4868327 | 0.77 | DRD2 (0.62) | HTR1ASIGMAR1DRD2HTR2AKDM4E | |
| SCHEMBL5846298 | 0.76 | SIGMAR1 (0.68) | HTR1ASIGMAR1DRD2HTR7PARP1 | |
| Hydrochloric Acid SCHEMBL5846785 | 0.75 | SIGMAR1 (0.67) | HTR1ASIGMAR1DRD2HTR7PARP1 | |
| SCHEMBL30764775 | 0.73 | HTR1A (0.82) | HTR1ASIGMAR1DRD2HTR2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4340597-A | 1-Substituted-4-aryl-1,2,5,6-tetrahydro and hexahydropyridines | SCHERING CORPORATION (US) | 1982-07-20 | — | — | US | claimed |
| US-4340597-A | 1-Substituted-4-aryl-1,2,5,6-tetrahydro and hexahydropyridines | SCHERING CORPORATION (US) | 1982-07-20 | — | — | US | disclosed |