Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.54 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496045 | 0.81 | TDP1 (0.70) | FFAR1RAB9ATDP1PTGDR2MAPT | |
| SCHEMBL4451807 | 0.81 | RAB9A (0.51) | ACLYFFAR1FFAR4LMNARAB9A | |
| SCHEMBL578719 | 0.80 | LMNA (0.64) | LMNARAB9ATDP1PTGDR2MAPT | |
| Ammonia Solution, Strong SCHEMBL8439387 | 0.80 | TDP1 (0.68) | FFAR1RAB9ATDP1PTGDR2MAPT | |
| SCHEMBL7044820 | 0.79 | FFAR4 (0.57) | ACLYSLC6A9FFAR1FFAR4PPARG | |
| SCHEMBL4343090 | 0.78 | PPARG (0.55) | LMNARAB9ATDP1PPARGPTGDR2 | |
| SCHEMBL29457684 | 0.78 | KDM4E (0.60) | LMNARAB9ATDP1PPARGMAPT | |
| SCHEMBL10746769 | 0.78 | KDM4E (0.60) | LMNARAB9ATDP1PPARGMAPT | |
| SCHEMBL10359783 | 0.78 | PPARG (0.67) | FFAR1FFAR4LMNARAB9ATDP1 | |
| SCHEMBL10833625 | 0.78 | S1PR4 (0.47) | ACLYSLC6A9LMNARAB9AESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017379-B1 | PHENYL OR PHENOXY SUBSTITUTED SPIRO-IMIDAZOLIDINEDIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND PROCESS FOR THEIR PREPARATION | PFIZER INC. (US) | 1982-09-08 | — | — | EP | disclosed |
| EP-0017379-A1 | Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives, pharmaceutical compositions thereof and process for their preparation | PFIZER INC. (US) | 1980-10-15 | — | — | EP | disclosed |
| US-4181729-A | ALDOSE REDUCTASE INHIBITORS, REDUCING DIABETES | PFIZER INC. (US) | 1980-01-01 | — | — | US | disclosed |