Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | CASP2 | P42575 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ACP1 | P24666 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11259222 | 0.80 | NPC1 (0.49) | NPC1MAPTALDH1A1LMNAACP1 | |
| SCHEMBL11258414 | 0.80 | CASP2 (0.64) | NPC1CASP2MAPTALDH1A1ACP1 | |
| SCHEMBL21589413 | 0.78 | NPC1 (0.65) | NPC1CASP2MAPTALDH1A1LMNA | |
| SCHEMBL27990525 | 0.78 | LMNA (0.69) | MAPTALDH1A1LMNAKDM4EALOX15 | |
| SCHEMBL4867128 | 0.78 | CASP2 (0.62) | NPC1CASP2ALDH1A1LMNAACP1 | |
| SCHEMBL4488390 | 0.78 | CASP2 (0.66) | NPC1CASP2MAPTALDH1A1ACP1 | |
| SCHEMBL29477216 | 0.75 | RAB9A (0.72) | NPC1CASP2MAPTALDH1A1LMNA | |
| SCHEMBL11920138 | 0.75 | RAB9A (0.72) | NPC1CASP2MAPTALDH1A1LMNA | |
| SCHEMBL4861743 | 0.74 | GAA (0.62) | NPC1CASP2MAPTALDH1A1LMNA | |
| SCHEMBL27676696 | 0.73 | CASP2 (0.60) | NPC1CASP2MAPTACP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344946-A | ANTIARTHRITICS, ANTIRHEUMATICS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-17 | — | — | US | disclosed |