SCHEMBL112689

SCHEMBL112689

Nc1cccc(F)c1Br

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10394885 0.97 CYP3A4 (0.38)
SCHEMBL2015386 0.80
SCHEMBL610147 0.80
SCHEMBL6009043 0.77 CES2 (0.39)
SCHEMBL601969 0.72
SCHEMBL59477 0.72
SCHEMBL491287 0.72
SCHEMBL31167436 0.72
SCHEMBL29803091 0.72
SCHEMBL724770 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 427 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108002976-B Preparation method of 1-fluoro-2-bromo-3-iodobenzene 金凯(辽宁)生命科技股份有限公司 2021-04-23 CN claimed
WO-1993019026-A1 PREPARATION OF 3-HALO-HALOBENZENES AND 1-HALO-3,5-DIHALOBENZENES MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) 1993-09-30 WO claimed
US-5157169-A Preparation of 3-halo-halobenzenes and 1-halo-3,5-dihalobenzenes MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) 1992-10-20 US claimed
US-12630566-B2 KRas G12D inhibitors Mirati Therapeutics, Inc. (US) 2026-05-19 US disclosed
US-12612414-B2 Nitrile SUMO inhibitors and uses thereof CIT THERAPEUTICS, INC. (US) 2026-04-28 US disclosed
US-12612424-B2 HPK1 inhibitors and uses thereof REGOR PHARMACEUTICALS, INC. (US) 2026-04-28 US disclosed
EP-4724427-A1 A PROCESS OF PREPARATION OF AN ANTIBACTERIAL COMPOUND AND ITS INTERMEDIATES THEREOF Bugworks Research, Inc. (US) 2026-04-15 EP disclosed
US-12577239-B2 Sulfilimines or sulfoximines containing fungicidal heterocyclic compounds PI INDUSTRIES LTD. (IN) 2026-03-17 US disclosed
EP-4121421-B1 BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS NOVARTIS AG (CH) 2026-03-11 EP disclosed
US-12559481-B2 Quinoline derivatives ELANCO ANIMAL HEALTH GMBH (DE) 2026-02-24 US disclosed
EP-4680612-A1 CHEMICAL COMPOUNDS AN2 Therapeutics, Inc. (US) 2026-01-21 EP disclosed
WO-2002008199-A2 EFFICIENT LIGAND-MEDIATED ULLMANN COUPLING OF ANILINES AND AZOLES BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2002-01-31 WO disclosed
EP-1161232-A1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2001-12-12 EP disclosed
WO-2001014354-A1 SUBSTITUTED 2-ARYLBENZAZOLE COMPOUNDS AND THEIR USE AS ANTITUMOUR AGENTS CANCER RESEARCH VENTURES LIMITED (GB) 2001-03-01 WO disclosed
WO-2000035442-A1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-06-22 WO disclosed
EP-0279548-B1 Substituted 1,3,4,9-tetrahydropyrano [3,4-b] indole-1-acetic acids AMERICAN HOME PRODUCTS CORPORATION (US) 1992-08-19 EP disclosed
US-4904799-A Preparation of tryptophols AMERICAN HOME PRODUCTS CORP. (US) 1990-02-27 US disclosed
US-4886886-A FORMED FROM TRIFLUOROACETANILIDE IN MULTISTEP PROCEDURE AMERICAN HOME PRODUCTS CORPORATION (US) 1989-12-12 US disclosed
US-4785015-A ANALGESICS, ANTIINFLAMMATORY AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1988-11-15 US disclosed
EP-0279548-A1 Substituted 1,3,4,9-tetrahydropyrano [3,4-b] indole-1-acetic acids AMERICAN HOME PRODUCTS CORPORATION (US) 1988-08-24 EP disclosed