Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11269374 | 0.81 | RAB9A (0.48) | TRPA1CYP3A4NPC1RAB9AMEN1 | |
| SCHEMBL10924639 | 0.81 | RAB9A (0.50) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL11291348 | 0.76 | CES2 (0.37) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL11293448 | 0.71 | GSK3B (0.45) | CYP3A4NPC1RAB9AMEN1MAPT | |
| SCHEMBL11262513 | 0.67 | NPC1 (0.33) | CYP3A4NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL5337050 | 0.65 | TRPA1 (0.51) | TRPA1CYP3A4MAPTL3MBTL1 | |
| SCHEMBL2379273 | 0.64 | — | — | |
| SCHEMBL15988633 | 0.64 | TRPA1 (0.69) | TRPA1CYP3A4NPC1RAB9AMEN1 | |
| SCHEMBL19813954 | 0.63 | TRPA1 (0.40) | TRPA1CYP3A4NPC1RAB9AMAPT | |
| SCHEMBL1515702 | 0.62 | GPR52 (0.54) | TRPA1CYP3A4NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044705-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | claimed |
| EP-0044705-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | disclosed |