Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 9/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11274142 | 0.88 | C5AR1 (0.62) | C5AR1CYP19A1MRGPRX1F2F10 | |
| SCHEMBL11246834 | 0.83 | C5AR1 (0.51) | C5AR1MRGPRX1F2F10PRSS1 | |
| SCHEMBL11284130 | 0.81 | CYP19A1 (0.44) | C5AR1CYP19A1BRD4 | |
| SCHEMBL11280329 | 0.79 | C5AR1 (0.47) | C5AR1MRGPRX1F2F10PRSS1 | |
| SCHEMBL11254295 | 0.77 | SGMS2 (0.47) | C5AR1CYP19A1BRD4F2F10 | |
| SCHEMBL7167350 | 0.77 | PPIA (0.47) | C5AR1BRD4 | |
| SCHEMBL11138186 | 0.77 | ALDH1A1 (0.48) | C5AR1 | |
| SCHEMBL11282564 | 0.76 | KDM4E (0.40) | C5AR1MRGPRX1F2F10PRSS1 | |
| SCHEMBL11265930 | 0.75 | C5AR1 (0.43) | C5AR1CYP19A1BRD4 | |
| SCHEMBL14868313 | 0.73 | TAS2R38 (0.45) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |