Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 9/20 | 0.38 |
| ▸ | HTR7 | P34969 | 9/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 3/20 | 0.37 |
| ▸ | HTR1B | P28222 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11273451 | 0.75 | DRD2 (0.53) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL822940 | 0.64 | HTR1A (0.61) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL823058 | 0.64 | HTR1A (0.61) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL1950024 | 0.64 | HTR1A (0.61) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL29507805 | 0.64 | HTR1A (0.61) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL11493897 | 0.64 | DRD2 (0.40) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL7410621 | 0.63 | HTR6 (0.53) | DRD2DRD4DRD3HTR1ACHRM3 | |
| Hydrochloric Acid SCHEMBL29064497 | 0.63 | HTR1A (0.59) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL31564615 | 0.63 | DRD2 (0.59) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL11269661 | 0.61 | SIGMAR1 (0.42) | DRD2DRD1DRD4DRD3HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014792-B1 | TETRAHYDRO-2H-BENZO(C)PYRROLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE AS THERAPEUTICALS | ELI LILLY AND COMPANY (US) | 1982-12-01 | — | — | EP | disclosed |
| US-4264622-A | TREATMENT OF PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4235776-A | USED FOR TREATMENT OF PARKINSON'S DISEASE, PROLACTIN INHIBITORS, AND DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |