SCHEMBL11270244

SCHEMBL11270244

COC(=O)CN(C(=O)CSC(=O)c1ccccc1)c1c(C)ccc(Cl)c1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.43
RAB9A P51151 1/20 0.38
ALDH1A1 P00352 9/20 0.37
MAPT P10636 6/20 0.37
GPR139 Q6DWJ6 1/20 0.36
L3MBTL1 Q9Y468 3/20 0.35
KDM4E B2RXH2 3/20 0.35
PRNP P04156 2/20 0.35
HTT P42858 1/20 0.34
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
MAPK1 P28482 1/20 0.33
HSD17B10 Q99714 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11270268 0.91 KMT2A (0.46) KMT2ARAB9AALDH1A1MAPTGPR139
SCHEMBL11494654 0.89 KMT2A (0.46) KMT2AALDH1A1MAPTGPR139L3MBTL1
SCHEMBL11265319 0.87 KMT2A (0.43) KMT2ARAB9AALDH1A1MAPTGPR139
SCHEMBL11276183 0.87 KMT2A (0.48) KMT2ARAB9AALDH1A1MAPTGPR139
SCHEMBL11277898 0.85 RAB9A (0.41) KMT2ARAB9AALDH1A1MAPTKDM4E
SCHEMBL11271232 0.84 RAB9A (0.40) KMT2ARAB9AALDH1A1MAPTL3MBTL1
SCHEMBL11279236 0.84 RORC (0.39) KMT2ARAB9AALDH1A1MAPTL3MBTL1
SCHEMBL11282776 0.84 ALDH1A1 (0.35) KMT2ARAB9AALDH1A1MAPTL3MBTL1
SCHEMBL11285126 0.83 RAB9A (0.39) KMT2ARAB9AALDH1A1MAPTKDM4E
SCHEMBL11284341 0.83 RAB9A (0.39) KMT2ARAB9AALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4313957-A Pesticidal sulfur containing amides derived from aniline and the method of preparation thereof RHONE-POULENC AGROCHIMIE (FR) 1982-02-02 US disclosed