Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068508 | 0.86 | LMNA (0.54) | LMNAPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL19242935 | 0.81 | KDM4E (0.66) | LMNAPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL5737176 | 0.80 | KDM4E (0.48) | LMNAKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL11277251 | 0.80 | KDM4E (0.46) | LMNAPDE3BPDE3AKDM4EALDH1A1 | |
| Pyridine SCHEMBL11278813 | 0.78 | PDE3B (0.42) | LMNAPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL11272074 | 0.78 | PDE3B (0.54) | LMNAPDE3BPDE3AKDM4EPPARA | |
| SCHEMBL27521128 | 0.77 | KDM4E (0.46) | LMNAPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL7802190 | 0.77 | PDE3B (0.51) | LMNAPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL11281640 | 0.77 | POLB (0.42) | LMNAPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL11273753 | 0.76 | TNKS2 (0.47) | LMNAPDE3BPDE3AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |