Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11277251 | 0.93 | KDM4E (0.46) | TNKS2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL11284124 | 0.82 | PDE3A (0.43) | TNKS2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL11278795 | 0.82 | MEN1 (0.43) | TNKS2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL11287721 | 0.80 | TNKS2 (0.44) | TNKS2KDM4EMCL1CYP1A2CYP2C19 | |
| SCHEMBL11273567 | 0.79 | KMT2A (0.45) | MAPTALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL11273755 | 0.78 | TNKS2 (0.42) | TNKS2ALDH1A1HPGDKDM4EHTT | |
| SCHEMBL11272206 | 0.76 | LMNA (0.48) | TNKS2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL11068508 | 0.76 | LMNA (0.54) | TNKS2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL11272074 | 0.76 | PDE3B (0.54) | TNKS2KDM4ELMNACYP1A2CYP2C19 | |
| SCHEMBL11287724 | 0.75 | TNKS2 (0.39) | TNKS2ALDH1A1HPGDKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |