SCHEMBL1127389

SCHEMBL1127389

CCCC(=CC(=O)O)NC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 4/20 0.40
HDAC1 Q13547 4/20 0.40
HDAC2 Q92769 4/20 0.40
HDAC8 Q9BY41 4/20 0.40
FFAR3 O14843 3/20 0.40
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
CTSD P07339 1/20 0.34
TSHR P16473 4/20 0.33
KDM4E B2RXH2 2/20 0.33
ATM Q13315 1/20 0.33
ALDH1A1 P00352 2/20 0.32
HCAR2 Q8TDS4 1/20 0.31
AKR1B1 P15121 1/20 0.31
PPARG P37231 3/20 0.30
PPARD Q03181 3/20 0.30
PPARA Q07869 3/20 0.30
GPR84 Q9NQS5 2/20 0.30
HDAC11 Q96DB2 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11747912 0.82 CES1 (0.36) HDAC3HDAC1HDAC2HDAC8FFAR3
SCHEMBL11747920 0.82 CES1 (0.36) HDAC3HDAC1HDAC2HDAC8FFAR3
SCHEMBL15101541 0.81
SCHEMBL1061979 0.80 HDAC3 (0.39) HDAC3HDAC1HDAC2HDAC8FFAR3
SCHEMBL5143662 0.78 HDAC3 (0.37) HDAC3HDAC1HDAC2HDAC8FFAR3
SCHEMBL7731866 0.78 HDAC3 (0.37) HDAC3HDAC1HDAC2HDAC8FFAR3
SCHEMBL10460626 0.77 NPSR1 (0.48) HDAC3HDAC1HDAC2HDAC8CES2
SCHEMBL10460628 0.77 NPSR1 (0.48) HDAC3HDAC1HDAC2HDAC8CES2
SCHEMBL21880239 0.75 CES2 (0.41) HDAC3HDAC1HDAC2HDAC8FFAR3
SCHEMBL15567985 0.75 CASP2 (0.46) ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9669243-B2 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate BASF SE (DE) 2017-06-06 US disclosed
WO-2012024652-A3 SYSTEM AND METHODS FOR IMPROVED EFFICIENCY COMPRESSION IGNITION INTERNAL COMBUSTION ENGINE CONTROL TULA TECHNOLOGY, INC. (US) 2012-05-10 WO disclosed
EP-2282716-A2 DELIVERY OF HYDROPHOBIC BENEFIT AGENTS FROM BODYWASHES AND THE LIKE ONTO A KERATINOUS SUBSTRATE BASF SE (DE) 2011-02-16 EP disclosed
US-20100135936-A1 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate BASF SE (DE) 2010-06-03 US disclosed
EP-2152230-A2 SUNSCREEN COMPOSTIONS COMPRISING A RANDOM TERPOLYMER BASF SE (DE) 2010-02-17 EP disclosed
EP-2129363-A2 SUNSCREEN AND PERSONAL CARE COMPOSITIONS COMPRISING A SELECT COPOLYMER BASF SE (DE) 2009-12-09 EP disclosed
WO-2009130144-A2 DELIVERY OF HYDROPHOBIC BENEFIT AGENTS FROM BODYWASHES AND THE LIKE ONTO A KERATINOUS SUBSTRATE BASF SE (DE) 2009-10-29 WO disclosed
WO-2008122516-A2 SUNSCREEN AND PERSONAL CARE COMPOSITIONS COMPRISING A SELECT COPOLYMER BASF SE (CH) 2008-10-16 WO disclosed
WO-2008122517-A2 SUNSCREEN COMPOSITIONS COMPRISING A RANDOM TERPOLYMER BASF SE (CH) 2008-10-16 WO disclosed
US-20080247975-A1 Sunscreen and personal care compositions comprising a select copolymer CIBA CORP. 2008-10-09 US disclosed
US-20080019929-A1 Micro-Particulate Organic Uv Absorber Composition CIBA SPECIALTY CHEMICALS CORP. 2008-01-24 US disclosed
EP-1784156-A1 MICRO-PARTICULATE ORGANIC UV ABSORBER COMPOSITION Ciba Specialty Chemicals Holding Inc. (CH) 2007-05-16 EP disclosed
WO-2006024633-A1 MICRO-PARTICULATE ORGANIC UV ABSORBER COMPOSITION CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2006-03-09 WO disclosed
EP-0893119-B1 UV-protection formulation CIBA SC HOLDING AG (CH) 2003-09-03 EP disclosed
EP-1089706-B1 SUN SCREEN FORMULATIONS CIBA SC HOLDING AG (CH) 2003-05-02 EP disclosed
US-6521217-B1 Pulverizating cosmetic carriers and ultraviolet radiation absorbers comprising triazines, amides, benzotriazoles or benzimidazoles, in water in oil or an oil-in-water emulsions to form protective coatings or suntan lotions CIBA SPECIALTY CHEMICALS CORPORATION 2003-02-18 US disclosed
US-6235271-B1 A SUNSCREEN AGENT COMPRISING A MICRONIZED ORGANIC ULTRAVIOLET ABSORBER, AN OIL SOLUBLE, NON-MICRONIZED ULTRAVIOLET ABSORBER AND/OR INORGANIC MICROPIGMENT AND A COPOLYMER OF ACRYLIC ACID-STYRENE AS HOLLOW SPHERE CIBA SPECIALTY CHEMICALS CORPORATION 2001-05-22 US disclosed
EP-1089706-A1 SUN SCREEN FORMULATIONS Ciba SC Holding AG (CH) 2001-04-11 EP disclosed
WO-1999066896-A1 SUN SCREEN FORMULATIONS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1999-12-29 WO disclosed
EP-0893119-A1 UV-protection formulation Ciba SC Holding AG (CH) 1999-01-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080247975-A1 Sunscreen and personal care compositions comprising a select copolymer MSH6, CUTA, ERCC5 HDAC3 2564/4885HDAC1 1829/4885HDAC2 2984/4885
US-20100135936-A1 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate KRT18, ABHD16A, CUTA HDAC3 2523/4885HDAC1 1709/4885HDAC2 2341/4885
US-20080019929-A1 Micro-Particulate Organic Uv Absorber Composition PCNA, FASN, CCNO HDAC3 4267/4885HDAC1 3236/4885HDAC2 3038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.