Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2756356 | 0.83 | ALDH1A1 (0.48) | ALDH1A1 | |
| SCHEMBL2145850 | 0.83 | ALDH1A1 (0.39) | CYP1A2CYP1A1CYP3A4CYP2D6CYP1B1 | |
| SCHEMBL6501170 | 0.80 | CYP19A1 (0.46) | KCNA5CYP1A2CYP1A1CYP3A4CYP2D6 | |
| SCHEMBL3903975 | 0.80 | CYP11B1 (0.44) | TSHRCFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL931178 | 0.79 | IDO1 (0.47) | ALDH1A1KMT2A | |
| SCHEMBL360712 | 0.79 | CFTR (0.57) | KCNA5ALDH1A1CFTRSLC6A2SLC6A4 | |
| Bromide SCHEMBL8069043 | 0.77 | CYP11B1 (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19CFTR | |
| SCHEMBL1515839 | 0.77 | KCNA5 (0.47) | KCNA5CYP1A2CYP1A1CYP3A4CYP2D6 | |
| SCHEMBL9602349 | 0.77 | KIF11 (0.48) | KCNA5CYP3A4ALDH1A1TSHRKMT2A | |
| SCHEMBL6505968 | 0.76 | CYP3A4 (0.49) | KCNA5CYP1A2CYP1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045081-A2 | Trisubstituted imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use | CIBA-GEIGY AG (CH) | 1982-02-03 | — | — | EP | disclosed |