Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7735911 | 0.92 | MITF (0.63) | HDAC3HDAC11HDAC8HDAC6MITF | |
| SCHEMBL15267699 | 0.82 | KMT2A (0.60) | HDAC3HDAC11HDAC8HDAC6MITF | |
| SCHEMBL11272129 | 0.78 | CA12 (0.56) | HDAC3HDAC11HDAC8HDAC6MITF | |
| SCHEMBL17361644 | 0.78 | HPGD (0.61) | HDAC3HDAC11HDAC8HDAC6MITF | |
| SCHEMBL13242331 | 0.76 | DGAT1 (0.51) | IDO1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL5868999 | 0.76 | SLC18A3 (0.63) | HDAC3HDAC11HDAC8HDAC6ALDH1A1 | |
| SCHEMBL12810977 | 0.76 | HDAC3 (0.57) | HDAC3HDAC11HDAC8HDAC6MITF | |
| SCHEMBL1039601 | 0.75 | KMT2A (0.76) | ALDH1A1HPGDNPC1KMT2ARAB9A | |
| SCHEMBL7888049 | 0.75 | CYP1A1 (0.60) | ALDH1A1HPGDNPC1KMT2ARAB9A | |
| SCHEMBL517540 | 0.75 | MITF (0.63) | HDAC3HDAC11HDAC8HDAC6MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4348396-A | Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them | HOFFMANN-LA ROCHE INC. (US) | 1982-09-07 | — | — | US | disclosed |