Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.63 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.56 |
| ▸ | RORC | P51449 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11274121 | 0.92 | HDAC3 (0.53) | MITFKLF5ALDH1A1HPGDNPC1 | |
| SCHEMBL517540 | 0.84 | MITF (0.63) | MITFKLF5ALDH1A1HPGDNPC1 | |
| SCHEMBL3824110 | 0.84 | MITF (0.63) | MITFKLF5ALDH1A1HPGDNPC1 | |
| SCHEMBL11356835 | 0.81 | HDAC8 (0.64) | MITFKLF5ALDH1A1HPGDNPC1 | |
| SCHEMBL11215485 | 0.80 | HDAC8 (0.62) | MITFKLF5ALDH1A1HPGDNPC1 | |
| SCHEMBL7940080 | 0.79 | MITF (0.58) | MITFKLF5ALDH1A1HPGDNPC1 | |
| SCHEMBL7738147 | 0.79 | ALDH1A1 (0.81) | MITFKLF5ALDH1A1HPGDNPC1 | |
| SCHEMBL15267699 | 0.78 | KMT2A (0.60) | MITFALDH1A1HPGDNPC1HDAC8 | |
| SCHEMBL7760744 | 0.78 | HDAC8 (0.60) | MITFKLF5ALDH1A1HPGDNPC1 | |
| SCHEMBL3822159 | 0.78 | SLC18A3 (0.67) | MITFKLF5ALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410792-B1 | OBESITY DISEASES | BAYER CORPORATION | 2002-06-25 | — | — | US | disclosed |
| US-6245817-B1 | NEUROPEPTIDE Y | BAYER CORPORATION | 2001-06-12 | — | — | US | disclosed |
| US-6048900-A | FOR TREATING EATING DISORDERS, INSULIN RESISTANT DIABETES, HYPERTENSION, HYPERLIPEMIA | BAYER CORPORATION (US) | 2000-04-11 | — | — | US | disclosed |
| US-5939462-A | ADMINISTERING ALKOXY AND -THIOALKOXYAMIDE COMPOSITIONS TO MAMMALS TO TREAT DISORDERS SUCH AS OBESITY THAT ARE MEDIATED BY NEUROPEPTIDE Y (?NPY?) | BAYER CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| EP-0927166-A1 | AMIDES AS NPY5 RECEPTOR ANTAGONISTS | Bayer Corporation (US) | 1999-07-07 | — | — | EP | disclosed |
| EP-0910565-A1 | AMIDE DERIVATIVES AS SELECTIVE NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Bayer Corporation (US) | 1999-04-28 | — | — | EP | disclosed |
| WO-1998035957-A1 | AMIDE DERIVATIVES AS SELECTIVE NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BAYER CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |
| WO-1998035944-A1 | AMIDES AS NPY5 RECEPTOR ANTAGONISTS | BAYER CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |