Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.73 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11452752 | 1.00 | ALOX5 (0.73) | ALOX5PTGDR2PTGS2ALDH1A1MAPT | |
| SCHEMBL11455410 | 0.93 | PTGS2 (0.66) | ALOX5PTGDR2PTGS2ALDH1A1MAPT | |
| SCHEMBL9666309 | 0.87 | ALOX5 (0.58) | ALOX5PTGDR2PTGS2ALDH1A1MAPT | |
| SCHEMBL11275957 | 0.87 | PTGDR2 (0.61) | ALOX5PTGDR2PTGS2ALDH1A1MAPT | |
| SCHEMBL9768642 | 0.86 | ALDH1A1 (0.62) | ALOX5PTGDR2PTGS2ALDH1A1MAPT | |
| SCHEMBL10506565 | 0.86 | PTGS2 (0.78) | ALOX5PTGDR2PTGS2ALDH1A1MAPT | |
| SCHEMBL7844066 | 0.86 | PTGS2 (0.59) | ALOX5PTGDR2PTGS2ALDH1A1MAPT | |
| SCHEMBL11275235 | 0.86 | ALOX5 (0.74) | ALOX5PTGDR2PTGS2ALDH1A1MAPT | |
| SCHEMBL4060584 | 0.84 | ALOX5 (0.69) | ALOX5PTGDR2ALDH1A1MAPTMEN1 | |
| SCHEMBL14148755 | 0.84 | PTGDR2 (0.60) | ALOX5PTGDR2ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322428-A | 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | claimed |
| US-4322428-A | 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0037274-A1 | Substituted triaryl thiazole compounds | ELI LILLY AND COMPANY (US) | 1981-10-07 | — | — | EP | disclosed |
| US-4197306-A | CONTROL OF INSECTS AND ACARIDS | UNIROYAL, INC. (US) | 1980-04-08 | — | — | US | disclosed |
| US-4153703-A | Method of controlling insects and acarids with certain aryl-substituted thiazoles | UNIROYAL, INC. (US) | 1979-05-08 | — | — | US | disclosed |