Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.61 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | DRD3 | P35462 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267287 | 0.88 | HTR1A (0.64) | HTR1DHTR1BHTR1ADRD2DRD3 | |
| SCHEMBL11500383 | 0.86 | HTR1D (0.47) | HTR1DHTR1BHTR1ADRD2DRD3 | |
| Maleic Acid SCHEMBL11280479 | 0.84 | ALDH1A1 (0.56) | HTR1DHTR1BHTR1ADRD2DRD3 | |
| SCHEMBL2599107 | 0.83 | HTR1A (0.76) | HTR1DHTR1BHTR1ADRD2DRD3 | |
| SCHEMBL2599112 | 0.83 | HTR1A (0.76) | HTR1DHTR1BHTR1ADRD2DRD3 | |
| Sulfuric Acid SCHEMBL11263748 | 0.81 | HTR1D (0.41) | HTR1DHTR1BHTR1ADRD2DRD3 | |
| SCHEMBL11269661 | 0.80 | SIGMAR1 (0.42) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL11268179 | 0.79 | DRD2 (0.50) | HTR1ADRD2DRD3MEN1KMT2A | |
| SCHEMBL8315256 | 0.76 | HTR1D (1.00) | HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL9752128 | 0.75 | DRD3 (0.59) | HTR1DHTR1BHTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014792-B1 | TETRAHYDRO-2H-BENZO(C)PYRROLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE AS THERAPEUTICALS | ELI LILLY AND COMPANY (US) | 1982-12-01 | — | — | EP | disclosed |
| US-4264622-A | TREATMENT OF PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4235776-A | USED FOR TREATMENT OF PARKINSON'S DISEASE, PROLACTIN INHIBITORS, AND DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |