Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | AHR | P35869 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | CDC25B | P30305 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29389855 | 0.86 | TSHR (0.70) | KDM4EPOLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL8927648 | 0.86 | TSHR (0.70) | KDM4EPOLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL24953219 | 0.86 | KDM4E (0.55) | KDM4EPOLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL18050536 | 0.84 | TSHR (0.54) | KDM4EPOLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL2900687 | 0.84 | KMT2A (0.65) | KDM4EPOLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL11983357 | 0.83 | TSHR (0.53) | KDM4EPOLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL620668 | 0.83 | ALDH1A1 (0.71) | KDM4EPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10900936 | 0.83 | TSHR (0.66) | KDM4EPOLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL28903404 | 0.82 | TSHR (0.51) | KDM4EPOLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL7229272 | 0.82 | KDM4E (0.56) | KDM4EPOLBMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283002-A2 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009134616-A2 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-05 | — | — | WO | disclosed |